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Description
Biotinylated CD79B Fc&Avi Tag Protein, HumanProduct Specification Species Human Synonyms CD79b, B29, IGB, Ig beta Accession P40259 1 Amino Acid Sequence Ala29 Asp159, with C hIgG1 Fc and Avitag Expression System HEK293 Molecular Weight 55 60 kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Human |
| Synonyms | CD79b, B29, IGB, Ig-beta |
| Accession | P40259-1 |
| Amino Acid Sequence | Ala29-Asp159, with C-hIgG1 Fc and Avitag |
| Expression System | HEK293 |
| Molecular Weight | 55-60 kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Dr Maria Corinna A Palanca-Wessels, Prof Myron Czuczman, Prof Gilles Salles, Sarit Assouline, Laurie H Sehn, Ian Flinn, et al; Safety and activity of the anti-CD79B antibody–drug conjugate polatuzumab vedotin in relapsed or refractory B-cell non-Hodgkin lymphoma and chronic lymphocytic leukaemia: a phase 1 study. ARTICLES| VOLUME 16, ISSUE 6, P704-715, JUNE 2015. . |
Background
CD79, the signaling component of the B-cell receptor (BCR), is a promising target of antibodies and ADCs for the treatment of B-cell malignancies and autoimmune diseases. CD79 is a heterodimer, consisting of CD79a and CD79b, and is an attractive target because it is B cell specific and is expressed in almost all forms of non-Hodgkin's lymphoma and most forms of chronic lymphocytic leukemia. CD79 is particularly attractive for use as an ADC because the receptor is trafficked to a lysosome-like compartment as part of antigen presentation, thereby providing a mechanism for enhancing the release of drug from the ADC.
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4.4 ★★★★★
Based on 1348 reviews
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Product Reviews
★★★★★ 4
Informative
Format: Paperback
This book was one of several college informaion books I checked out from our local library. This one was the best - informative, objective and not-too-lengthy or not-too-short for each important element of college selection and application processes. So, I decided to buy one to keep at home. I wish the paper is thicker and better quality. Whenever I use highlighter, it got through its back-page.
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Reviewed in the United States on June 19, 2013
★★★★★ 5
Excellent advice
Format: Paperback
I've been working in College Student Affairs for almost 10 years (admissions & academic advising.) I bought this as a gift for my godson, who was a sophomore in high school at the time. I chose this book because it didn't put pressure on kids to pick the big name school with the highest price tag they were accepted to. It gave good advice bout finding out and figuring out what schools would be a good "fit" for them. It also had some good advice about taking & prepping for the SATs - which made it a good choice fod my godson even though he is a couple years away from filling out his applications!
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Reviewed in the United States on January 18, 2012
★★★★★ 5
Highly Recommended
Format: Paperback
Superb book that eased my parental anxieties and has proven very helpful to my college-applicant daughter. Even though it was published in 2011, it is *not* dated (something I worried about). Sure, it will probably need an update by 2020 or so, but most of the info is not very time-sensitive to begin with.
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Reviewed in the United States on February 5, 2017
★★★★★ 3
Good place to start
Format: Paperback
I am an independent college adviser based in California and I recommend this book to my clients but only at the very beginning of the process (mostly to the parents of rising high school freshmen and sophomores).
This book is a good place to start especially for many of the foreign educated or immigrant families, who are new to the US College Admission process. The parents do tell us that the book loses its effectiveness once they gain knowledge of the process and/or they begin working one-on-one with an independent and/or become more conscious about meeting the high school counselors early in the process.
I personally like the fact that once this book is overviewed by the families, we can spend more time addressing specific concerns and giving more customized advice. As a result we only need quarterly meetings and these meetings are extremely targeted.
The problem with this book though is it reads like a huge information session by colleges. Those of you who have attended some of the information sessions will know what I mean. The insights provided by the deans and admission officers of various colleges sound somewhat like a "sales pitch" at times and at other times are misleading. I also recommend my students to keep their knowledge up to date by referring to various free resources such as Nancy Griesemer's educational articles in Washington Examiner Online, or the Choice Blog. I spend considerable time volunteering my services at a high school in a mixed/low income neighborhoods; I wish the price had been more reasonable considering that this is a basic book.
Lastly as members of NACAC (National Association of College Admission Counseling), all of us in the admissions field (College Admission Officers, High School Counselors, and Independent Counselors) subscribe to certain codes of ethics and one of the Statements of Good Practice says this about Fairness and Equity: We believe our members have a responsibility to treat one another and students in a fundamentally fair and equitable manner. Unfortunately, Ms. Mamlet and Ms. VanDeVelde do a great disservice by being disrespectful to a large community of Independent College Advisers, many of whom are needed when the high school counselors are juggling with case loads of 200-300 students each and are unable to keep up with the changing scene of college admissions (either due to the lack of funding or time). Gone are the days when people went to some "quack-independents" who promised admissions to Ivy Leagues--sure there are some of those but if families are careful in their research, they will soon find out that these Independents do not belong to any authentic professional organizations such as the NACAC, HECA or IECA. Most students who come to the authentic professionals are motivated to find their right fit college, explore their own strengths and weaknesses and find the best match for their talents, interests and financial situation. Most independents offer services that are reasonably priced. If Ms. Mamlet and VanDeVelde show more commitment to researching folks on the other side of the spectrum, I am sure that their book will be more enlightening.
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Reviewed in the United States on August 18, 2013
★★★★★ 5
Best College Info Book Ever!
Format: Paperback
I have read dozens of college-related books in the past 4 years, and this one ranks the highest by far. Written by industry experts and the authors got a lot of top talent to contribute. Full of real-life advice and useful information that is actually true (I fact-checked this against some other info).
I read parts of it out loud to my junior on the plane en route to a college tour, and she actually listened! Humor is always appreciated, and these authors use it without going overboard.
Great information, well-presented. A must-read!
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Reviewed in the United States on February 22, 2013